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1

SNTF immunostaining reveals previously undetected axonal pathology in traumatic brain injury

Johnson, Victoria E., Stewart, William, Weber, Maura T., Cullen, D. Kacy, Siman, Robert, Smith, Douglas H.

Journal:

Acta Neuropathologica

Year:

2016

Language:

english

File:

PDF, 3.79 MB

english, 2016

2

Evidence That the Blood Biomarker SNTF Predicts Brain Imaging Changes and Persistent Cognitive Dysfunction in Mild TBI Patients

Siman, Robert, Giovannone, Nicholas, Hanten, Gerri, Wilde, Elisabeth A., McCauley, Stephen R., Hunter, Jill V., Li, Xiaoqi, Levin, Harvey S., Smith, Douglas H.

Journal:

Frontiers in Neurology

Year:

2013

Language:

english

File:

PDF, 574 KB

english, 2013

3

Nonpeptidic inhibitors of recombinant human calpain I

Sankar Chatterjee, Shobha Senadhi, Donna Bozyczko-Coyne, Robert Siman, John P. Mallamo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 182 KB

english, 1997

4

K-252a Induces Tyrosine Phosphorylation of the Focal Adhesion Kinase and Neurite Outgrowth in Human Neuroblastoma SH-SY5Y Cells

Anna Coco Maroney, Lorraine Lipfert, M. Elizabeth Forbes, Marcie A. Glicksman, Nicola T. Neff, Robert Siman, Craig A. Dionne

Journal:

Journal of Neurochemistry

Year:

1995

Language:

english

File:

PDF, 1.56 MB

english, 1995

5

Comparison of Calpain and Caspase Activities in the Adult Rat Brain after Transient Forebrain Ischemia

Chen Zhang, Robert Siman, Y.Anne Xu, Angela M. Mills, James R. Frederick, Robert W. Neumar

Journal:

Neurobiology of Disease

Year:

2002

Language:

english

File:

PDF, 987 KB

english, 2002

6

Authors' response to commentaries

David S. Howland, Barry D. Greenberg, Mary J. Savage, Robert Siman, Richard W. Scott

Journal:

Neurobiology of Aging

Year:

1995

Language:

english

File:

PDF, 455 KB

english, 1995

7

Caspase-3 activation in oligodendrocytes from the myelin-deficient rat

Jacqueline S. Beesley, LeaAnn Lavy, Nuri B. Eraydin, Robert Siman, Judith B. Grinspan

Journal:

Journal of Neuroscience Research

Year:

2001

Language:

english

File:

PDF, 180 KB

english, 2001

8

Calpain Facilitates the Neuron Death Induced by 3-Nitropropionic Acid and Contributes to the Necrotic Morphology

Pang, Zhen, Bondada, Vimala, Sengoku, Tomoko, Siman, Robert, Geddes, James W.

Journal:

Journal of Neuropathology and Experimental Neurology

Year:

2003

Language:

english

File:

PDF, 876 KB

english, 2003

9

The Role of Calpail-Mediated Spectrin Proteolysis in Traumatically Induced Axonal Injury

Büki, András, Siman, Robert, Trojanowski, John Q., Povlishock, John T.

Journal:

Journal of Neuropathology and Experimental Neurology

Year:

1999

File:

PDF, 958 KB

1999

10

Potent α-ketocarbonyl and boronic ester derived inhibitors of proteasome

Mohamed Iqbal, Sankar Chatterjee, James C. Kauer, John P. Mallamo, Patricia A. Messina, Alyssa Reiboldt, Robert Siman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 160 KB

english, 1996

11

Exploration of the importance of the P2-P3 -NHCO-Moiety in a potent di- or tripeptide inhibitor of calpain i: insights into the development of nonpeptidic inhibitors of calpain I

Sankar Chatterjee, Mohamed Iqbal, Satish Mallya, Shobha E. Senadhi, Teresa M. O’Kane, Beth Ann McKenna, Donna Bozyczko-Coyne, James C. Kauer, Robert Siman, John P. Mallamo

Journal:

Bioorganic & Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 257 KB

english, 1998

12

Regulation of glutamate receptor binding by the cytoskeletal protein fodrin

Siman, Robert, Baudry, Michel, Lynch, Gary

Journal:

Year:

1985

File:

PDF, 549 KB

1985

13

Developmental status of neurons selectively vulnerable to rapidly triggered post-ischemic caspase activation

Zhaoming Chen, Diana Kontonotas, Daniel Friedmann, Alex Pitts-Kiefer, James R. Frederick, Robert Siman, Robert W. Neumar

Journal:

Neuroscience Letters

Year:

2005

Language:

english

File:

PDF, 367 KB

english, 2005

14

Reframing the Biological Basis of Neuroprotection Using Functional Genomics: Differentially Weighted, Time-Dependent Multifactor Pathogenesis of Human Ischemic Brain Damage

Kofke, William A., Ren, Yue, Augoustides, John G., Li, Hongzhe, Nathanson, Katherine, Siman, Robert, Meng, Qing Cheng, Bu, Weiming, Yandrawatthana, Sukanya, Kositratna, Guy, Kim, Cecilia, Bavaria, Jos

Journal:

Frontiers in Neurology

Year:

2018

Language:

english

File:

PDF, 1.04 MB

english, 2018

15

Evidence That Wallerian Degeneration and Localized Axon Degeneration Induced by Local Neurotrophin Deprivation Do Not Involve Caspases

Finn, John T., Weil, Miguel, Archer, Fabienne, Siman, Robert, Srinivasan, Anu, Raff, Martin C.

Journal:

Journal of Neuroscience

Year:

2000

Language:

english

File:

PDF, 442 KB

english, 2000

16

β-Amyloid precursor is a PEST protein

Robert Siman, Greg Christoph

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 550 KB

english, 1989

17

Distribution of calpain I, an enzyme associated with degenerative activity, in rat brain

Robert Siman, Christine Gall, Lynn S. Perlmutter, Clifford Christian, Michel Baudry, Gary Lynch

Journal:

Year:

1985

Language:

english

File:

PDF, 2.65 MB

english, 1985

18

Xanthene derived potent nonpeptidic inhibitors of recombinant human calpain I

Sankar Chatterjee, Mohamed Iqbal, James C. Kauer, John P. Mallamo, Shobha Senadhi, Satish Mallya, Donna Bozyczko-Coyne, Robert Siman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 230 KB

english, 1996

19

Caspase-mediated cell death predominates following engraftment of neural progenitor cells into traumatically injured rat brain

Asha Bakshi, Carrie A. Keck, Vadim S. Koshkin, David G. LeBold, Robert Siman, Evan Y. Snyder, Tracy K. McIntosh

Journal:

Year:

2005

Language:

english

File:

PDF, 676 KB

english, 2005

20

Potent Inhibitors of Proteasome

Iqbal, Mohamed, Chatterjee, Sankar, Kauer, James C., Das, Manoj, Messina, Patricia, Freed, Bethany, Biazzo, William, Siman, Robert

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 254 KB

english, 1995

21

Increased Expression of IL-1Î² Converting Enzyme in Hippocampus after Ischemia: Selective Localization in Microglia

Bhat, Ratan V., DiRocco, Richard, Marcy, Val R., Flood, Dorothy G., Zhu, Yuan, Dobrzanski, Pawel, Siman, Robert, Scott, Richard, Contreras, Patricia C., Miller, Matthew

Journal:

Journal of Neuroscience

Year:

1996

File:

PDF, 1.03 MB

1996

22

Perikaryal accumulation and proteolysis of neurofilament proteins in the post-mortem rat brain

James W. Geddes, Vimala Bondada, Tina L. Tekirian, Zhen Pang, Robert G. Siman

Journal:

Neurobiology of Aging

Year:

1995

Language:

english

File:

PDF, 2.47 MB

english, 1995

23

Turnover of Amyloid Î²-Protein in Mouse Brain and Acute Reduction of Its Level by Phorbol Ester

Savage, Mary J., Trusko, Stephen P., Howland, David S., Pinsker, Leonard R., Mistretta, Suzanne, Reaume, Andrew G., Greenberg, Barry D., Siman, Robert, Scott, Richard W.

Journal:

Journal of Neuroscience

Year:

1998

File:

PDF, 347 KB

1998

24

Subsite requirements for peptide aldehyde inhibitors of human calpain I

Mohamed Iqbal, Patricia A. Messina, Bethany Freed, Manoj Das, Sankar Chatterjee, Rabindranath Tripathy, Ming Tao, Kurt A. Josef, Bruce Dembofsky, Derek Dunn, Eric Griffith, Robert Siman, Shobha E. Sen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 329 KB

english, 1997

25

Regional distribution and time-course of calpain activation following kainate-induced seizure activity in adult rat brain

Xiaoning Bi, Vanessa Chang, Robert Siman, Georges Tocco, Michel Baudry

Journal:

Year:

1996

Language:

english

File:

PDF, 6.70 MB

english, 1996

26

Biologically active monomeric and heterodimeric recombinant human calpain I produced using the baculovirus expression system

MEYER, Sheryl L., BOZYCZKO-COYNE, Donna, MALLYA, Satish K., SPAIS, Chrysanthe M., BIHOVSKY, Ron, KAWOOYA, John K., LANG, Diane M., SCOTT, Richard W., SIMAN, Robert

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 380 KB

english, 1996

27

Glutamate receptor antagonists inhibit calpain-mediated cytoskeletal proteolysis in focal cerebral ischemia

Stephen L Minger, James W Geddes, Mary L Holtz, Susan D Craddock, Sidney W Whiteheart, Robert G Siman, L.Creed Pettigrew

Journal:

Year:

1998

Language:

english

File:

PDF, 10.86 MB

english, 1998

28

Combination therapy prevents amyloid-dependent and -independent structural changes

Gauri Malthankar-Phatak, Shane Poplawski, Nikhil Toraskar, Robert Siman

Journal:

Neurobiology of Aging

Year:

2012

Language:

english

File:

PDF, 4.17 MB

english, 2012

29

The ultrastructural localization of calcium-activated protease “calpain” in rat brain

Lynn S. Perlmutter, Robert Siman, Christine Gall, Peter Seubert, Michel Baudry, Gary Lynch

Journal:

Year:

1988

Language:

english

File:

PDF, 5.24 MB

english, 1988

30

Glutamate Neurotoxicity Is Independent of Calpain I Inhibition in Primary Cultures of Cerebellar Granule Cells

Hari Manev, Marco Favaron, Robert Siman, Alessandro Guidotti, Erminio Costa

Journal:

Journal of Neurochemistry

Year:

1991

Language:

english

File:

PDF, 2.16 MB

english, 1991

31

FAD mutant PS-1 gene-targeted mice: increased Aβ42 and Aβ deposition without APP overproduction

Dorothy G Flood, Andrew G Reaume, Karen S Dorfman, Yin-Guo Lin, Diane M Lang, Stephen P Trusko, Mary J Savage, Wim G Annaert, Bart De Strooper, Robert Siman, Richard W Scott

Journal:

Neurobiology of Aging

Year:

2002

Language:

english

File:

PDF, 482 KB

english, 2002

32

A Panel of Neuron-Enriched Proteins as Markers for Traumatic Brain Injury in Humans

Siman, Robert, Toraskar, Nikhil, Dang, Antony, McNeil, Elizabeth, McGarvey, Micheal, Plaum, Justin, Maloney, Eileen, Grady, M. Sean

Journal:

Journal of Neurotrauma

Year:

2009

Language:

english

File:

PDF, 23.88 MB

english, 2009

33

Engaged for Change: A Community-Engaged Process for Developing Interventions to Reduce Health Disparities

Rhodes, Scott D., Mann-Jackson, Lilli, Alonzo, Jorge, Simán, Florence M., Vissman, Aaron T., Nall, Jennifer, Abraham, Claire, Aronson, Robert E., Tanner, Amanda E.

Journal:

AIDS Education & Prevention

Year:

2017

Language:

english

File:

PDF, 124 KB

english, 2017

34

A CBP Binding Transcriptional Repressor Produced by the PS1/ϵ-Cleavage of N-Cadherin Is Inhibited by PS1 FAD Mutations

Philippe Marambaud, Paul H Wen, Anindita Dutt, Junichi Shioi, Akihiko Takashima, Robert Siman, Nikolaos K Robakis

Journal:

Year:

2003

Language:

english

File:

PDF, 544 KB

english, 2003

35

Regional distribution of soluble calcium activated proteinase activity in neonatal and adult rat brain

Lisa Simonson, Michel Baudry, Robert Siman, Gary Lynch

Journal:

Year:

1985

Language:

english

File:

PDF, 541 KB

english, 1985

36

APP transgenesis: Approaches toward the development of animal models for Alzheimer disease neuropathology

Barry D. Greenberg, Mary J. Savage, David S. Howland, Shujath M. Ali, Sandi L. Siedlak, George Perry, Robert Siman, Richard W. Scott

Journal:

Neurobiology of Aging

Year:

1996

Language:

english

File:

PDF, 2.50 MB

english, 1996

37

Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo

Siman, Robert, Carl Noszek, J.

Journal:

Year:

1988

Language:

english

File:

PDF, 2.47 MB

english, 1988

38

Strategies to alter the progression of Alzheimer's disease

Robert Siman, Richard W. Scott

Journal:

Current Opinion in Biotechnology

Year:

1996

Language:

english

File:

PDF, 670 KB

english, 1996

39

Aurintricarboxylic Acid Protects Hippocampal Neurons from NMDA-and Ischemia-Induced Toxicity In Vivo

Jill M. Roberts-Lewis, Val R. Marcy, Yonghua Zhao, Jeffry L. Vaught, Robert Siman, Michael E. Lewis

Journal:

Journal of Neurochemistry

Year:

1993

Language:

english

File:

PDF, 559 KB

english, 1993

40

A Rapid Gene Delivery–Based Mouse Model for Early-Stage Alzheimer Disease–Type Tauopathy

Siman, Robert, Lin, Yin-Guo, Malthankar-Phatak, Gauri, Dong, Yina

Journal:

Journal of Neuropathology and Experimental Neurology

Year:

2013

Language:

english

File:

PDF, 12.95 MB

english, 2013

41

Specificity of Muscarinic Acetylcholine Receptor Regulation by Receptor Activity

Robert G. Siman, William L. Klein

Journal:

Journal of Neurochemistry

Year:

1981

Language:

english

File:

PDF, 985 KB

english, 1981

42

The Involvement of Proteases, Protease Inhibitors, and an Acute Phase Response in Alzheimer's Disease

HUNTINGTON POTTER, ROBERT B. NELSON, SAUMYA DAS, ROBERT SIMAN, USAMAH S. KAYYALI, DAVID DRESSLER

Journal:

Annals of the New York Academy of Sciences

Year:

1992

Language:

english

File:

PDF, 1.16 MB

english, 1992

43

Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage

Siman, Robert, Patrick Card, J., Nelson, Robert B., Davis, Leonard G.

Journal:

Year:

1989

Language:

english

File:

PDF, 15.88 MB

english, 1989

44

P2-achiral, P'-extended α-ketoamide inhibitors of calpain I

Sankar Chatterjee, Derek Dunn, Ming Tao, Gregory Wells, Zi-Qiang Gu, Ron Bihovsky, Mark A. Ator, Robert Siman, John P. Mallamo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 209 KB

english, 1999

45

Temporal Profiles of Cytoskeletal Protein Loss following Traumatic Axonal Injury in Mice

Gulyeter Serbest, Matthew F. Burkhardt, Robert Siman, Ramesh Raghupathi, Kathryn E. Saatman

Journal:

Neurochemical Research

Year:

2007

Language:

english

File:

PDF, 383 KB

english, 2007

46

Novel surrogate markers for acute brain damage: cerebrospinal fluid levels corrrelate with severity of ischemic neurodegeneration in the rat

Siman, Robert, Zhang, Chen, Roberts, Victoria L, Pitts-Kiefer, Alex, Neumar, Robert W

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

2005

Language:

english

File:

PDF, 349 KB

english, 2005

47

Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition

Michael N. DeRidder, Melissa J. Simon, Robert Siman, Yves P. Auberson, Ramesh Raghupathi, David F. Meaney

Journal:

Neurobiology of Disease

Year:

2006

Language:

english

File:

PDF, 890 KB

english, 2006

48

Distinct Nuclear and Cytoplasmic Localization of Caspase Cleavage Products in Two Models of Induced Apoptotic Death in Dopamine Neurons of the Substantia Nigra

Tinmarla F. Oo, Robert Siman, Robert E. Burke

Journal:

Experimental Neurology

Year:

2002

Language:

english

File:

PDF, 240 KB

english, 2002

49

Presenilin P264L knock-in mutation: Differential effects on abproduction, amyloid deposition, and neuronal vulnerability

Robert Siman, Andrew G. Reaume, Mary J. Savage, Richard W. Scott, Dorothy G. Flood

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 187 KB

english, 2000

50

O2-02-03: Evidence that amyloid deposition impairs adult hippocampal neurogenesis

Robert Siman, Chen Zhang, Elizabeth McNeil, Lindsay Dressler, Antony Dang

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 70 KB

english, 2008

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